Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

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Tumor and Stem Cell Biology Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of human breast tumor transcriptomes and experiments using cancer cell lines and xenografts. However, in vivo genetic experimental support for a role for SNAIL1 in breast cancer metastasis that develops in an immunocompetent tumor microenvironment has not been determined. To address this question, we created a gene...

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Transient SNAIL1 expression is necessary for metastatic competence in breast cancer.

SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of human breast tumor transcriptomes and experiments using cancer cell lines and xenografts. However, in vivo genetic experimental support for a role for SNAIL1 in breast cancer metastasis that develops in an immunocompetent tumor microenvironment has not been determined. To address this question, we created a gene...

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ژورنال

عنوان ژورنال: Cancer Research

سال: 2014

ISSN: 0008-5472,1538-7445

DOI: 10.1158/0008-5472.can-14-0923